2022 · Multidisciplinary clinical guidance
WPATH — Standards of Care, Version 8
Open-access standards addressing care for transgender and gender-diverse people across clinical contexts.
Read source ↗GENDER / CARE / EVIDENCE
Transgender Health & Research
Identity, medicine, outcomes, and the freedom to ask better questions.
Transgender and gender-diverse lives are not reducible to diagnoses or medical interventions. Some people pursue hormones or surgery; others do not. This page treats identities with respect while collecting clinical guidance and contemporary studies of care and outcomes.
Research findings have different strengths. A clinical guideline summarizes professional recommendations; a systematic review synthesizes multiple studies; an observational cohort can show associations without proving causation. Those distinctions matter.
Clinical guidance and definitions
Starting points for understanding care, not instructions for self-prescribing.
2017 guideline · Society reference page updated 2024
Endocrine Society — Gender Dysphoria / Gender Incongruence Guideline
Evidence-based endocrine guidance on gender-affirming hormone care. Consult the page for updates and the original guideline date.
Read source ↗Clinical reference · Revision status noted on site
UCSF — Guidelines for Primary and Gender-Affirming Care
Practical clinical topics from primary care and hormones to preventive screening; its site notes that revisions are forthcoming.
Read source ↗WHO · Classification overview
WHO — Gender Incongruence and Transgender Health in the ICD
Explains why ICD-11 moved gender incongruence out of the mental-disorders chapter.
Read source ↗Studies and evidence reviews
A few entry points into the recent research record.
2025 · EClinicalMedicine · Systematic review
Cooney et al. — Gender-Affirming Hormones in Adults
Synthesizes evidence on health, quality of life, preferences, and costs in adults; discusses substantial limitations in study certainty.
Read source ↗2025 · EClinicalMedicine · Systematic review
Cooney et al. — Gender-Affirming Care in Adults
Examines psychosocial, hormonal, and surgical gender-affirming care outcomes across multiple study designs.
Read source ↗2025 · JAMA Network Open · Cohort study
Reisner et al. — Hormone Therapy and Depressive Symptoms
Reports an association between hormone therapy and lower rates of moderate-to-severe depressive symptoms in a primary-care cohort; observational evidence is not proof of causation.
Read source ↗Accessible starting point
For people looking for explanations instead of journal articles.
Educational guides · LGBTQ+ youth focus
The Trevor Project — Gender Identity Resources
Readable introductions to gender, pronouns, coming out, and supporting trans and nonbinary people.
Read source ↗Resource list compiled November 6, 2026. Links, services, and evidence may change.
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